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KMID : 0350519950480020515
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Journal of Catholic Medical College
1995 Volume.48 No. 2 p.515 ~ p.528
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Expression of Epidermal Growth (F? Recent? A?) by In Situ mRNA Hyvbridization in (?)
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Abstract
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Activation of epidermal growth factor receptor (EGFR) has been known to result in cell proliferation and differentiation. Overexpression of EGFR either by gene amplification or increased gene transcription has been reported in several types of
tumors.
However, EGFR expression and/or its prognostic value in prostatic adenocarcinoma has been controversia.
EGFR expression in prostate is probably under androgenic control and EGFR expression in prostatic adenocarcinoma after castration has been reported to be decreased.
The purpose of this study is to examine the correlation between EGFR expression of prostatic adenocarcinoma by in situ EGFR-mRNA hybridization method and prostatic hyperplasia, Gleason grading system, clinical stage, androgen dependence and
independence
of the tumor, change after orchiectomy, and its relation to overall survival rate and survival duration in 34 patients with prostatic adenocarcinoma.
@ES The results were as follows ;
@EN 1. All prostatic adenocarcinoma and benign prostatic hyperplasia demonstrated cytoplasmic EGFR message, but EGFR intensity score of prostatic adenocarcinoma was significantly higher than that of benign prostatic hyperplasia (P<0.05).
2. EGFR intensity score of the patients with high Gleason score(8-10) was significantly higher than that of the patients with low Gleason score (2-4) (P<0.05).
3. EGFR intensity score of clinical stage C was significantly lower than that of clinical stage D (P<0.05), and EGFR intensity score of clinical stage D1 was almost the same as that of clinical stage D2.
4. There was no significant difference of EGFR intensity score between androgen-dependent and androgen-independent prostatic adenocarcinoma at each Gleason grade.
5. After castration, expression of EGFR was showed in all androgen-dependent and androgen-independent prostatic adenocarcinoma, but EGFR intensity score was significantly decreased at each Gleason grade as compared to that of androgen-dependent
and
androgen-independent prostatic adenocarcinoma before castration (P<0.05).
6. In case of EGFR intensity score higher than 2.5, 5 year survival rate was significantly lower than that of EGFR intensity score lower than 2.5 (P<0.05), and actual survival duration was significantly shorter than that of EGFR intfensity score
lower
than 2.5 (P<0.05).
These results suggest that prostatic adenocarcinoma may lose the normal androgen-EGFR relationship and the degree of EGFR expression may be important for the prediction of prognosis.
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KEYWORD
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